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This guidance supports the thresholds of LSM 815 kPa by VCTE for the selection of treatment candidates with semaglutide, as this is in line with the IQR of LSM by VCTE in ESSENCE and aligns with prior AASLD guidance on selecting individuals who meet the resmetirom treatment indications based on fibrosis stage

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In general: Baseline testing helps identify pre-existing issues before starting GLP-1 therapy Early follow-up (812 weeks) checks how your body is responding Ongoing testing may be spaced out or symptom-driven if results are stable and you feel well Most clinicians prioritize trend analysis over isolated single results

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